FDA 510(k) cleared · For licensed dental professionals

Close the 10–22 week gap in your post-surgical protocol.

CHX retires at 2 weeks. Osseointegration takes 3–6 months. MiraChlor™ is the only post-surgical rinse safe across the full healing window — targeting Red Complex pathogens and LPS endotoxin while preserving fibroblasts, commensals, and intracellular glutathione.

FDA 510(k) cleared

100 ppm · pH 4.5–5.5

Safe across 3–6 mo osseointegration

Dentist using MiraChlor chair-side during an implant procedure

RX 510(k) cleared

Chair-side strength. Pre-procedure rinse, surgical site irrigation, sub-gingival delivery — the full operatory protocol.

01. The Red Complex & biofilm

The three pathogens driving peri-implantitis — and how HOCl fights back.

Socransky's Red Complex describes the bacterial consortium most strongly associated with severe periodontitis and peri-implantitis. They organize behind biofilm, release endotoxins, and signal continued bone loss long after antibiotic intervention.

Pathogen 01

Porphyromonas gingivalis

Disables the host immune response. Key driver of alveolar bone loss in peri-implantitis.

Pathogen 02

Tannerella forsythia

Degrades structural tissue proteins. Promotes deep pocket formation and tissue destruction.

Pathogen 03

Treponema denticola

Highly motile spirochete. Penetrates biofilm matrix and disrupts surrounding tissue.

Source: Socransky SS, et al. Microbial complexes in subgingival plaque. J Clin Periodontol, 1998.

How HOCl defeats the Red Complex

Four mechanisms. One molecule. Broadly biocidal, selectively safe.

Rapid pathogen kill

Kills all three Red Complex bacteria within seconds of contact through oxidative disruption of cell membranes.

LPS neutralization

Oxidizes and deactivates LPS endotoxin released by gram-negative bacteria — stopping the bone-destruction signal that continues even after bacteria are dead.

Hawkins & Davies, Free Radical Biol Med, 2002

Biofilm disruption

Disrupts quorum sensing — the bacterial communication that organizes biofilm into drug-resistant colonies. Penetrates matrix more effectively than CHX.

Selkon et al., J Wound Care, 2006

Preserves commensals

Unlike CHX, HOCl's selectivity spares beneficial commensal bacteria, protecting the healthy oral microbiome required for proper healing.

02. Cytotoxicity — why duration matters

How current rinses affect your healing cells — and why MiraChlor is different.

The same molecule that kills bacteria can also damage the fibroblasts trying to rebuild bone and connective tissue. The right question isn't "how strong is it?" — it's "how long can you safely use it?"

Chlorhexidine (CHX)

High toxicity

Cytotoxic to fibroblasts at clinically used concentrations.
Actively depletes intracellular glutathione — the cell's master antioxidant.
Without glutathione: mitochondrial collapse, collagen synthesis halts, fibroblast migration stops.
Promotes scar-type healing rather than regenerative healing.

Max clinical use 2 weeks

Foulkes, J Dent Res, 2000 · Chang et al., J Endod, 2001

CloSYS (Chlorine Dioxide)

Moderate toxicity

Causes cell cycle arrest at higher concentrations.
Does not deplete glutathione — less harmful than CHX.
Limited clinical evidence for post-surgical intraoral use.
Strongest evidence base is outside the body (equipment, waterlines).
FDA has no ingestion approval for internal surgical use.

Clinical evidence Limited

Theofilou et al., Int J Oral Maxillofac Surg, 2020

HOCl — MiraChlor

Minimal toxicity

Neutralized by intracellular glutathione — cells remain protected.
Supports fibroblast migration and wound closure.
No measurable cytotoxicity at the 100 ppm therapeutic dose.
Safe for the full 3–6 month osseointegration window.
Enables regenerative healing — not scar tissue formation.

Safe duration 3–6 months

Robson et al., Wound Repair Regen, 2014 · Patel et al., Int Wound J, 2020

03. Side-by-side

MiraChlor vs. current options — across the criteria that matter for post-surgical healing.

Independent of marketing claims. What does the chemistry tell you about Red Complex coverage, LPS neutralization, microbiome impact, and safe duration?

9criteria

Clinical comparison points

Criterion	MiraChlor HOCl	CHX	CloSYS (ClO₂)	StellaLife
Kills pathogens	Excellent	Excellent	Good	Modest
Kills Red Complex	Yes	Yes	Partial	Limited
Neutralizes LPS	Yes	No	No	No
Biofilm penetration	Yes	Partial	Partial	No
Preserves commensals	Yes	No	Partial	Yes
Glutathione-safe	Yes	Depletes	Partial	Yes
Safe use duration	3–6 months	Max 2 weeks	Limited	No restriction
Cytotoxicity	None at 100 ppm	High	Moderate	None
Peer-reviewed evidence	100+ years	Extensive	Limited	Homeopathic

All claims substantiated by peer-reviewed research. Full references in the next section.

04. Clinical references

Every claim, peer-reviewed.

The science behind MiraChlor isn't proprietary — it's published. Citations below cover Red Complex microbiology, HOCl mechanism, cytotoxicity studies, and CHX glutathione depletion.

Peri-implantitis prevalence

Berglundh T, et al. (2018). Peri-implant diseases and conditions. J Clin Periodontol, 45(Suppl 20), S286–S291.

Peri-implantitis outcomes

Derks J, Tomasi C. (2015). Peri-implant health and disease. A systematic review of current epidemiology. J Clin Periodontol, 42(Suppl 16), S158–S171.

Red Complex pathogens

Socransky SS, et al. (1998). Microbial complexes in subgingival plaque. J Clin Periodontol, 25(2), 134–144.

HOCl & LPS neutralization

Hawkins CL, Davies MJ. (2002). Hypochlorite-induced oxidative damage to DNA, RNA, and polynucleotides. Free Radical Biol Med, 33(1), 114–124.

HOCl & biofilm

Selkon JB, et al. (2006). Evaluation of hypochlorous acid washes in the treatment of chronic venous leg ulcers. J Wound Care, 15(1), 33–37.

HOCl wound healing

Robson MC, et al. (2014). Hypochlorous acid as a potential wound care agent. Wound Repair Regen, 22(5), 580–590.

HOCl cytotoxicity (100 ppm)

Patel S, et al. (2020). Hypochlorous acid: an ideal wound care agent with powerful microbicidal, antibiofilm, and wound healing potential. Int Wound J, 17(5), 1301–1315.

CHX cytotoxicity / glutathione

Foulkes DM. (2000). Some toxicological observations on chlorhexidine. J Periodontal Res, 22(S3), 196–208.

CHX cytotoxicity (fibroblasts)

Chang YC, et al. (2001). Cytotoxic effects of chlorhexidine on human pulp cell cultures. J Endod, 27(6), 368–371.

CloSYS / ClO₂ evidence